capsiplex'in orjinal klinik çalışmaları ve çıkan sonuçlar aşağıdadır. Capsiplex'in günde 278 kalori yaktığı bilimsel olarak kanıtlanmıştır. Capsiplex'in hiçbir yan etkisi ve başka bir ilaçla etkileşimi yoktur. Günde fazladan 278 kalori tükettiğinizde yani bazı günler fazla kaçırdığınızda Capsiplex sizin bir kurtarıcınız olacaktır. Capsiplex sizin formda kalmanızı sağlayacak, fazla kilonuz varsa bunları yok edecektir.

• Study 1: 100 mg Capsimax (2 mg Capsaicinoids) x 8 days x 8 subjects
• Study 2: 100 mg x 14 subjects x 14 days
• Study 3: 500 mg x 6 subjects x 8 days
• Study 4: 1000 mg x 6 subjects x 8 days

Capsimax Pilot Clinical Clearly Establishes:

• Tolerated well
• Positive Impact on Resting Metabolic Rate-the primary indicator of thermogenesis
• Positive Indicators on Body Mass Index

• Capsaicinoids enhance thermogenesisCapsaicinoids increase energy expenditureCapsaicinoids enhance loss of calories
• Capsaicinoids help reduce caloric intake

• Yoshioka M, et al: Effects of red-pepper diet on the energy metabolism in men., J Nutr Sci Vitaminol 1995; 41: 647-656.
• Yoshioka M, et al: Effects of red pepper added to high-fat & high-carbohydrate meals on energy metabolism & substrate utilization in

Japanese women. BrJ Nutr 1998; 80: 503-510.

• Westerterp-Plantenga MS, et al: Oral and gastrointestinal satiety effects of capsaicine on food intake (Abstract). I

Int J Obes Relat Metab Disord 2004; 28(Suppl. 1):S35.

• Yoshioka M, et al: Maximum tolerable dose of red pepper decreases fat intake independently of spicy sensation in the mouth.

Br J Nutr 2004; 91: 991-995.  

Red Pepper and Capsaicinoids Clinically Proven 

• Capsaicinoids stimulates carbohydrate oxidation
• Capsaicinoids burns carbs
• Capsaicinoids stimulates fat oxidation
• Capsaicinoids burns fat

• Yoshioka M, et al: Effects of red-pepper diet on the energy metabolism in men.

J Nutr Sci Vitaminol 1995; 41: 647-656.

• Lim K, et al: Dietary red pepper ingestion increases carbohydrate oxidation at rest and during exercise in runners.

Med Sci Sports Exerc 1997; 29: 355-61. Yoshioka M, et al: Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanse women. BrJ Nutr 1998; 80: 503-510.

• Yoshioka M, et al: Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol 1995; 41: 647-656.

Red Pepper and Capsaicinoids 
Clinically Proven 

• Several International Studies demonstrate Weight Management Benefits in Humans
• Other Benefits:
  • Capsaicinoids reduce oxidative stress
  • Capsaicinoids have an antioxidant effect

• Kempaiah RK, et al: Influence of dietary curcumin, capsaicin and garlic on the antioxidant status of red blood cells and the liver

in high-fat-fed rats. Ann Nutr Metab. 2004 Sep-Oct;48(5):314-20. Epub 2004 Oct 1.

• Lee CY, et al: Short-term control of capsaicin on blood and oxidative stress of rats in vivo.

Phytother Res. 2003May;17(5):454-8. Yoshioka M, Lim K, Kikuzato

                                                            Composition 

Capsimax™ Plus Blend Consists of:

• Capsicum Fruit Extract
• Caffeine Anhydrous
• Black Pepper Extract (Piperine)
• Niacin

Capsimax™ Plus Blend Clinical Study Design 

• Double-blind
• Randomized
• Placebo controlled
• Cross-over
• 25 subjects
• Study conducted at the University Oklahoma

Visit 1 

• Medical history
• Vital signs and weight
• Blood samples for laboratory analyses

Visits 2 and 3 

• Subjects took either Capismax™ Plus Blend or a placebo
• Served as their own control group, as half the group took Capismax™ Plus Blend on one day and then a placebo on a subsequent visit and the other half took the placebo first, then Capismax™ Plus Blend
• One week washout period between the two sessions

Visits 2 and 3 

Subjects were monitored during four periods as follows:

• a resting baseline period of 30 minutes prior to dosing
• a resting pre-exercise period of 60 minutes prior to exercise
• a 60 minute exercise period of moderate intensity (walking on treadmill)
• a resting 50 minute post-exercise period

Visit 4 

• Adverse events were recorded,
• Vital signs and weight were taken, and
• Blood samples for laboratory tests.

Background Variable 

• height (cm)
• weight (kg)
• heart rate (bpm)
• systolic blood pressure (mmHg)
• diastolic blood pressure (mmHg)

Outcome Variables 

• energy expenditure (Kcal/day)
• oxygen consumption (ml/kg/min)
• ventilation (L/Min)
• respiratory quotient
• rating of perceived exertion
• heart rate (bpm
• systolic blood pressure (mmHg)
• diastolic blood pressure (mmHg)

Capsimax™ Plus Blend Clinical Study Results 

• Upon baseline adjustment, statistical analysis indicated that when the subjects took Capsimax™Plus, they burned
  • 3-times more calories before exercise,
  • 3% more calories during, and

·         12 times more calories for upto one hour after exercise compared to when they took placebo.

• This resulted in an average cumulative total of 278 more calories burned before, during and after exercise compared to placebo.

Other effects 

• Given the notable increase in energy expenditure following treatment with Capismax™ Plus Blend, it is not surprising that other metabolic parameters related to energy expenditure also rose.
• For instance, subjects taking Capismax™ Plus Blend also experienced 7.5% greater oxygen uptakeduring the exercise period and greater air flow through the lungs during the post-exercise period than those taking placebo.
• Despite the fact that Capismax™ Plus Blend takers were expending more energy than placebo takers, they did not perceive they were exerting themselves more.

What is 278 calories worth? 

• 1 hour and 20 minutes of walking at a moderate pace (2 mph)**
• 25 minutes of jogging (10 minute mile, 6 mph)**
• 1 hamburger
• 1 slice of cheese pizza
• 2 chocolate chip cookies
• 1/2 bagel with 1 T cream cheese

Consuming extra 278 calories per day can result in weight gain of over 25 pounds in one year!